Mission

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Our mission

To sustain clinic, biomolecular and genetic research. To implement supervision and prevention of high risk pregnancies. To achieve the goal of reducing negative outcomes and fetal adult diseases due to the highly risk pregnancies.

The goals

  • To increase laboratory and echographic equipment useful for knowledge enhancement.

  • To implement the supervision and prevention of high risk pregnancies and pre-pregnancy counselling for mothers and fathers.

  • To improve neonatal care quality.

  • To improve follow-up of women who had highly risk pregnancy.

  • To implement the follow-up of infants born from highly risk pregnancies which requires a biomolecular genetic, echographic , auxologic, behavioural and nutrigenomic approach , and collaboration among parents, paediatrician and the organizations taking care of infants and children.

  • To spread “fetal adult disease” concept knowledge, through media advice . Lifestyle and prevention may improve the outcomes and reduce the fetal adult disease rate.

  • To implement the scientific grounding through Symposiums, Scientific Congress, stages attending and scientific multidisciplinary researches, in cooperation with Italian and International Centers.

  • To fund grants and employment contracts for young investigators.

The project

The research association was born by an idea of Dr. Benito Cappuccini, who found, with a group of colleagues, a clinic-scientific project in the Department of Maternal Infant Care of Perugia Hospital.

Background

High risk pregnancies (maternal diabetes, obesity, hypertension, preterm delivery, IUGR, assisted reproduction, congenital infections, particularly in older women) are 20% of total deliveries, with an increase of 10% per year. Women with a previous pathologic pregnancy represent a high risk population for subsequent development of diabetes, hypertension, obesity. The offsprings are a high risk population for perinatal damages and poor outcomes: cardiovascular metabolic syndrome (so far the first cause of morbility and mortality in developed countries), renal insufficiency, handicaps, behaviour and intellectual performance reduction, infertility. These pathologies originate from conception (ART-pregnancies have a 2-fold higher risk of gestational diabetes, 17-fold higher risk of epigenetic disorders) during pregnancy and during the neonatal period, due to the epigenetic mechanism, named “Fetal Adult Disease“: genetic changes are still unknown.